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Name Professor Rentala Madhubala
(Professor Rentala Madhubala)
FNA ID P11-1549
Address Professor and Director, School of Life Sciences, Jawaharlal Nehru University, Human Resource Development Centre, JNU
City New Delhi
Pin Code 110067
Country India
Gender Female
Specialization Molecular Parasitology, Functional genomics
Service in the Council
Qualification PhD
Membership FASc, FNASc, FNAMS
  Award
  Year of Election 2011  
E-mail madhubala@mail.jnu.ac.in; rentala@hotmail.com
Personal Website http://www.jnu.ac.in/Faculty/madhubala
Summary

 Our Research is on Kala-azar, a major public health problem endemic in parts of India. We are following a four pronged approach to eliminate this scourge: develope a drug to treat it, identify biomarkers for drug resistance in clinical isolates, devlope a vaccine to prevent it and identify the mechanism of host-parasite interaction. We have identified novel drug targets like vitamin c biosynthesis pathway, aminoacyltRNA synthetases, hypusine and glyoxalase pathwa. We have worked out the mechanism of resistance in clinical isolates to antimonials and also to paromomycin drugs commonly used for the treatment . We have recently developed a genetically attenuated live  parasite deficient in making ascorbic acid. These attenuated parasites were potent imunogens and act as a virulence factor by modulating host immune responses. These live attenuated parasites were found to be good vaccine candidate against visceral leishmaniasis (Mol. Microbiology, 2014, Nature Scientific Reports, 2015). we for the first time demonstrate the novel regulatory role of host microRNA, MIR30A-3p in modulation of host cell autophagy after infection with L. donovani. Our work shows that the host-MIR-30A-3p could be a potential new biomarker for L. donovani infection (Autophagy, 2016)..

 

 

 

 


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