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Name Dr KVR Chary
(Dr Chary)
FNA ID P12-1569
Address Senior Professor (I), Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba
City Mumbai
Pin Code 400005
Country
Gender Male
Specialization Molecular Biophysics, Structural Biology and NMR Spectroscopy
Service in the Council
Qualification PhD
Membership FNASc
  Award Professor R K Asundi Memorial Lecture (2006)
AK Bose Memorial Medal (1989)
INSA Medal for Young Scientists (1986)
  Year of Election 2012  
E-mail chary@tifr.res.in
Personal Website http://www.tifr.res.in/~chary
Summary

Kandala Venkata Ramana Chary did his BSc from Osmania University, MSc (Physics) from Osmania University, PhD (Physics) from Osmania University in 1983 and Joined Tata Institute of Fundamental Research (TIFR) in 1983. He was a Visiting Scientist in the laboratory of Professor Kurt Wuthrich, NL, at the Institute of Molecular Biology and Biophysics, Eidg. Technische Hochschule, Zurich, Switzerland (1988-90). Thereafter, he has been serving at TIFR in various capacities and currently is a Senior Professor (I).
 
Academic and Research Achievements: Guided by the dictum that structure and dynamics reflect the design of function, Prof. K.V.R. Chary unveiled important biomolecular 3D structures by NMR, such as Ca2+-binding proteins from Entamoeba histolytica, bg-crystallins and biologically rare DNA forms, and studied their conformational heterogeneity and dynamics. NMR is ideally suited for characterizing the solution structures of biomolecules at atomic resolution and the ruggedness of the native states of the proteins. However, macromolecules with sizes beyond a few tens of kilo-Daltons are not easily impregnable by NMR. Newer NMR methodologies are still in the hunt. It is here that Chary’s contributions are relevant. His work demonstrates several milestones in the development of new NMR methodologies and their application: i) Chary’s work on biologically rare DNA forms unveiled structural insights on duplex mismatches, hair-pin bends and strand disproprotionation in adopting triplex structures. Most intriguingly, he showed that triplexes are subject to strand slippages in one setting, while in another the same act as a rigid hindrance for incoming DNA replication (An un-anticipated DNA dynamics). ii) He demonstrated the capability of solving complete 3D-solution structures of proteins by NMR in India, for the first time during the last several years and continues to lead this pursuit. Recent studies on archael bgƒ{crystallin show its uncanny similarity with mammalian lens crystallins, an evolutionary convergent change. iii) He has developed newer methodologies to enhance the resolution and sensitivity of NMR spectra. He has developed rapid NMR methodologies, which speed up the acquisition and analysis of multidimensional NMR data by several orders of magnitude and push the boundary of NMR capability. Thus, on several counts, Chary’s contributions are novel and deeply connected with the underlying biology. To sum up, Chary’s research work elegantly combines high-resolution 3D structural and dynamics information with that of judicious mix of other supporting biophysical tools to achieve a wholesome understanding of the system on hand. Several of these approaches have yielded first time milestones. He published over 130 research articles in journals and written chapters in several books. He has guided 15 PhD students and 4 post-docs. Besides, Prof. Chary has co-authored a book entitled “NMR in Biological Systems: From Molecules to Humans” (Springer, 2008).
 
Other Contributions: He is a member, IUPAB National Committee of INSA (2012-16). President of “Indian Biophysical Society” (2011-2013).Executive Secretary, International Conferences on Magnetic Resonance in Biological Systems (ICMRBS), (2010-2012).Chairman, Royal Society of Chemistry, West India Section, (2010-2012).Sectional President of the “NEW BIOLOGY” section of 96th Session of Indian Science Congress, 2008-2009.Vice-Chairman, Royal Society of Chemistry, West India Section, (2005-2009).Fellow of Royal Society in Chemistry (FRSC), Royal Society in Chemistry, UK, (2004-till date ).Member of the International Union for Pure and Applied Biophysics (IUPAB) “Task Force on NMR of Biological Systems” (2002-till date).Council Member, International Conferences on Magnetic Resonance in Biological Systems (ICMRBS), (2005-2014).Executive Council Member, International Conferences on Magnetic Resonance in Biological Systems (ICMRBS), (2005-Current).Member and Scientific Secretary, Organizing Committee of the XXI International Conference on Magnetic Resonance in Biological Systems (XXI ICMRBS), held at Hyderabad, India, during January 16-21, 2005.Member, Project Management Committee of the 600 MHz NMR Facility, Indian Institute of Chemical Biology, Kolkata (2006-present). Executive Council Member, Indian Biophysical society (2000-04).Executive Council Member and Secretary, Indian Biophysical Society (2008-2011).Member Management Board for Homi Bhabha Centre for Science Education, TIFR, Mumbai-5 (2008-2011). He is co-PI of National Facility for High Field NMR. He is invited to speak at various national and international conferences and work-shops. He is invited to educate the post-graduate teachers and researchers on NMR spectroscopy during various National Work-Shops held under Continuing Education Programs/Faculty Refresher Courses.
 
Awards and Honours: Chary is the recipient of several awards and honours that include: Fellow, Andhra Pradesh Academi of Sciences (Hyderabad), 2011. Professor J.C.Ghosh Memorial Award of the Indian Chemical Society, 2009.The "Dharamsi Morarji Chemical Co. Visiting Fellowship in Chemistry" of the Institute of Chemical Technology, Mumbai, for the year 2010. Professor Rango Krishna Asundi Memorial Lecture Award of Indian National Science Academy, New Delhi 2006. Fellow, National Academy of Sciences, India, India (Allahabad), 2000. Anil Kumar Bose Memorial Award, Indian National Science Academy, New Delhi 1989, Young Scientist Award, BRUKER, 1986.
 

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